![]() ![]() Both variants 1 and 2 encode the same protein. Status: REVIEWED Description Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. ![]() See identical proteins and their annotated locations for NP_004889.1 NM_004898.4 → NP_004889.1 circadian locomoter output cycles protein kaput Location: 496 → 686 Med15 ARC105 or Med15 subunit of Mediator complex non-fungal cl25986 Location: 109 → 175 PAS PAS fold pfam09606 A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region HLH forms homo- and heterodimers. Location: 32 → 86 HLH Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors 60-100 amino acids long. ![]() Status: REVIEWED Description Transcript Variant: This variant (1) represents the longer transcript. See identical proteins and their annotated locations for NP_001254772.1 This section to the one reported in Genomic regions, Identify version mismatches by comparing the version of the RefSeq in These reference sequences are curated independently of the genomeĪnnotation cycle, so their versions may not match the RefSeq versions in the current These reference sequences exist independently of genome builds. Preferred Names circadian locomoter output cycles protein kaput Names circadian locomoter output cycles kaput protein class E basic helix-loop-helix protein 8 clock homolog NP_001254772.1 Expression Ubiquitous expression in testis (RPKM 7.8), thyroid (RPKM 6.2) and 24 other tissues See more Orthologs mouse all NEW Try the new Gene table Alternative splicing results in multiple transcript variants. Polymorphisms in this gene may be associated with behavioral changes in certain populations and with obesity and metabolic syndrome. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. The encoded protein forms a heterodimer with ARNTL (BMAL1) that binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. The protein encodes a transcription factor of the basic helix-loop-helix (bHLH) family and contains DNA binding histone acetyltransferase activity. Full Name clock circadian regulator provided by HGNC Primary source HGNC:HGNC:2082 See related Ensembl:ENSG00000134852 MIM:601851 AllianceGenome:HGNC:2082 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Euarchontoglires Primates Haplorrhini Catarrhini Hominidae Homo Also known as KAT13D bHLHe8 Summary The protein encoded by this gene plays a central role in the regulation of circadian rhythms. ![]()
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